The binhex documentation has a line in it that says "As of this writing, hexbin() appears to not work in all cases."

This is a bit ambiguous and there is no context for what the bug may be. It appears this line is from the first commit to the hexbin function's documentation in 1995 (https://hg.python.org/cpython/rev/3911d4a89ab0#l4.40) but the commit also has no information about what this bug may be. I also see no current open bugs for the binhex module that seem related.

In 2009, there was a patch for the hexbin function but I have no idea if this is the bug from the original documentation or if it was something else entirely: https://bugs.python.org/issue6369

Given this, I believe the line should be removed unless more details about the referenced buggy behavior can be found.