GCS has a new feature (currently in private alpha) wherein buckets can be configured to send object change notifications to Cloud Pub/Sub topics, rather than as push notifications to HTTPS endpoints.

For gcloud-python, I imagine such a feature might look like this:

from gcloud import pubsub
from gcloud import storage

storage_client = storage.Client()
pubsub_client = pubsub.Client()
bucket = storage_client.get_bucket(BUCKET_ID)
topic = pubsub_client.topic(TOPIC_ID)
notification_config = bucket.send_notifications_to(topic)