Unable to run with Python debug library

Environment

Pythonnet version: master@ f2dc8f1
Python version: 3.6 (probably others)
Operating System: Ubuntu 20.04 (probably others)
.NET Runtime: netcore 3.1, mono

Details

While debugging a build failure in Fix exception refcnt #1402 , I tried to use a debug build of python,

note: Python 3.6 was installed from the deadsnakes PPA.

Repro:

Install Python debug packages
Create a and use a virtual environment using the Python debug executable
Apply/cherry-pick filmor@ee3503b to run with a static libpython
change the dotnet_config to "debug" (line ~43 in setup.py)
run python -m pythonnet.find_libpython --export and export the result in the environment, make sure it points to the debug library
python setup.py develop then run pytest (with either --runtime mono or --runtime netcore)
It will error out with:

Failed to initialize pythonnet: System.TypeInitializationException: The type initializer for 'Delegates' threw an exception. ---> System.MissingMethodException: Failed to load symbol PyModule_Create2: /home/user/dev/36-dbg/bin/python: undefined symbol: PyModule_Create2
  at Python.Runtime.Platform.LinuxLoader.GetFunction (System.IntPtr dllHandle, System.String name) [0x00050] in <12881a58dd5544c59504de515c25928b>:0
  at Python.Runtime.Runtime+Delegates.GetFunctionByName (System.String functionName, System.IntPtr libraryHandle) [0x00000] in <12881a58dd5544c59504de515c25928b>:0
  at Python.Runtime.Runtime+Delegates..cctor () [0x01793] in <12881a58dd5544c59504de515c25928b>:0
   --- End of inner exception stack trace ---
  at Python.Runtime.Runtime.PyGILState_Ensure () [0x00000] in <12881a58dd5544c59504de515c25928b>:0
  at Python.Runtime.Loader.Initialize (System.IntPtr data, System.Int32 size) [0x0003c] in <12881a58dd5544c59504de515c25928b>:0
  at Python.Runtime.Runtime.PyGILState_Ensure () [0x00000] in <12881a58dd5544c59504de515c25928b>:0
  at Python.Runtime.Loader.Initialize (System.IntPtr data, System.Int32 size) [0x0003c] in <12881a58dd5544c59504de515c25928b>:0 INTERNALERROR> Traceback (most recent call last):
INTERNALERROR>   File "/home/user/dev/36-dbg/lib/python3.6/site-packages/_pytest/main.py", line 265, in wrap_session

If I fix that, there's another error in the TypeOffsets ctor (all offsets are null)