HumanCyc: Encyclopedia of Human Genes and Metabolism
Heme, Not Just the Red Pigment in Blood.
Heme, an iron-containing porphyrin, functions as a prosthetic group in numerous proteins. These range from components of the electron transport chain to many enzymes. No wonder the biosynthesis of heme is highly conserved in evolution!
Navigate Metabolic Map for Pathways
The Cellular Overview enables you to browse through a zoomable metabolic map diagram that displays pathways according to groups based on biological function, or classes of metabolites produced/consumed.
Cellular overview image generated by Pathway Tools
Important Mammalian Pathways: The Urea Cycle
The urea cycle is responsible for mediating excretion of nitrogenous waste. It was the first metabolic pathway to be discovered, five years before the discovery of the TCA cycle. The cycle occurs across both the cytosol and the mitchondrion.
RouteSearch: Search for Paths through the Metabolic Network
Search for lowest-cost paths through the metabolic network of the selected organism. Or, design lowest-cost pathways to novel compounds by adding reactions from MetaCyc.
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A Pathway Linked to Central Nervous System Disorders
The GABA shunt forms a closed loop in the CNS for conserving the supply of the excitatory neurotransmitter GABA. One of the enzymes of this pathway, 4-aminobutyrate aminotransferase is a target for the anti-epileptic drug vigabatrin.
Metabolomics Data Analysis
Multiple tools are available in this website for metabolomics data analysis.
SmartTable display generated by Pathway Tools.
The Truth about the Thanksgiving Turkey...
Of the 20 amino acids, at least 9 are essential. Essential L-tryptophan is required for serotonin, melatonin and niacin synthesis. Its requirement for NAD biosynthesis was discovered when humans stricken with pellagra recovered after the addition of tryptophan or niacin to their diets.
Gene Expression Data Analysis
Multiple tools are available in this website for analysis of gene expression data.
Cellular Overview Omics Viewer image generated by Pathway Tools.
HumanCyc provides an encyclopedic reference on human metabolic pathways, the human genome, and human metabolites.
HumanCyc is part of the larger BioCyc collection of thousands of Pathway/Genome Databases for sequenced genomes. Click the "Change Current Database" button above to explore the available databases.
For more information on HumanCyc, see our article "Computational prediction of human metabolic pathways from the complete human genome" in Genome Biology.
"BsubCyc is a tool of the utmost value."
Paul Babitzke
Prof. of Biochemistry
& Molecular Biology
"My lab uses these resources on a daily basis."
Patricia Kiley,
Professor and Chair,
Dep't. of Biomolecular Chemistry
"We rely on BioCyc's Gene Pages and Overview Diagrams almost daily."
Arkady Khodursky
Assoc. Prof. Biochemistry
"We use BioCyc and MetaCyc extensively to investigate the metabolic and regulatory processes of organisms we study."
William Cannon, Team Lead
Computational Biology
"BioCyc is the go-to resource of knowledge and tools for Ginkgo scientists."
"BioCyc is a tremendous resource for pathway analysis in metabolomics."
Art Edison, Dept of Genetics
"We make extensive use of the BioCyc full metabolic network diagram for omics data analysis."
Timothy J. Donohue, Director
"I have not found another database that has a better interface than BioCyc."
Gary B. Huffnagle, Professor
Microbiology and Immunology