Add Custom shortcut keys

If you have a shortcut anywhere on the Start Menu or Desktop you can create a keyboard shortcut for it.

For example if you have a shortcut to the traditional Control Panel in the Start Menu, right click it and choose More ➞ Open file location. Right click on the shortcut file and select Properties. Under Shortcut ➞ Shortcut Key you can assign a hotkey,
pressing Ctrl+C will assign the shortcut Ctrl+Alt+C. Shortcuts can also start with Ctrl + Shift

When launching a program via its shortcut key, Window will first poll all currently running programs and ask "Is this your shortcut key?" If so it switches focus to that window rather than opening a new copy of the program. A delay of several seconds can occur when a window somewhere refuses to respond. This can be a program that’s generally non-responsive or running/sleeping as a background process.

How to disable one or more ⊞ (Windows Key) Keyboard Shortcuts:

In the Windows registry add a new String Value called “DisabledHotkeys" under HKCU\Software\Microsoft\CurrentVersion\Explorer\Advanced

Set the value data for this key to the hotkey characters you want to disable.
For example: to disable the hotkeys Win + X and Win + R, set the value to RX
(n.b. This will also affect other modifier key combinations like Win + Shift + X)

Restart Explorer or Logoff/reboot and the new settings will apply to this user account.

The hotkeys specified will be disabled and unassigned and thus available to any third party app which allows you to assign global hotkeys.