Clopamide

Also found in: Medical.

Clopamide
Clinical data


AHFS/Drugs.com	International Drug Names
ATC code	C03BA03 (WHO)
Identifiers
IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl- benzamide
CAS Number	636-54-4
PubChem CID	2804
ChemSpider	2702
UNII	17S83WON0I
KEGG	D02460
ChEMBL	ChEMBL1361347
CompTox Dashboard (EPA)	DTXSID1022847
ECHA InfoCard	100.010.238
Chemical and physical data
Formula	C₁₄H₂₀ClN₃O₃S
Molar mass	345.84 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
InChI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N
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Clopamide (trade name Brinaldix) is a piperidine diuretic.^[1]

Mechanism of action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

^ McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784.

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