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PKA may refer to:
- Parkour Amersfoort
- Professionally known as:
- Pen name
- Stage persona
- pKa, the symbol for the acid dissociation constant at logarithmic scale
- Protein kinase A, a class of cAMP-dependent enzymes
- Pi Kappa Alpha, the North-American social fraternity
- Public key authentication, establishing key authenticity in public-key cryptography
- Professional Karate Association
- Primary knock-on atom, an atom that is displaced from its lattice site by irradiation
- Painkiller Already, a podcast featuring FPSRussia
- Pentax KA-mount, a camera lens mount
Non-Latin
- The Latin letters PKA are visually similar to the Cyrillic acronym РКА, the Russian Federal Space Agency
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