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1. COBRApy is a package for constraint-based modeling of metabolic networks.

   Python 555 234

2. optlang - sympy based mathematical programming language

   Python 269 52

3. cameo - computer aided metabolic engineering & optimization

   Python 123 45

4. memote – the genome-scale metabolic model test suite

   HTML 146 33

5. Simple swig bindings for the GNU Linear Programming Kit

   Python 30 10

6. Mass Action Stoichiometric Simulation (MASS) Toolbox

   Mathematica 12 8